Pilot study of Trigeminal Nerve Stimulation (TNS) for epilepsy: A proof-of-concept trial

Abstract

The safety and preliminary efficacy of trigeminal nerve stimulation (TNS) for epilepsy was evaluated in a pilot feasibility study of transcutaneous stimulation of the infraorbital and supraorbital branches of the trigeminal nerve. TNS was well tolerated. Four (57%) of seven subjects who completed ≥3 months experienced a ≥50% reduction in seizure frequency. The results of this pilot study support further investigation into the safety and efficacy of TNS for epilepsy. © 2006 International League Against Epilepsy.