Enzymatic Noncovalent Synthesis for Mitochondrial Genetic Engineering of Cancer Cells

Abstract

Enzymatic noncovalent synthesis (ENS), a process generating supramolecular interactions and higher-order molecular ensembles via enzymatic reactions, achieves the formation of molecular assemblies at mitochondria, which facilitates gene delivery for mitochondrial genome editing in a cancer-specific manner. Illustrating mitochondrial ENS to deliver various cargos for genetic engineering of cancer mitochondria, this work by He et al. offers a promising strategy for targeting mitochondria of cancer cells and for understanding the correlation between mitochondria and cancer.