Toxin detection in patients' sera by mass spectrometry during two outbreaks of type A botulism in France

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Abstract

In two outbreaks of food-borne botulism in France, Clostridium botulinum type A was isolated and characterized from incriminated foods. Botulinum neurotoxin type A was detected in the patients' sera by mouse bioassay and in vitro endopeptidase assay with an immunocapture step and identification of the cleavage products by mass spectrometry. Copyright © 2012, American Society for Microbiology. All Rights Reserved.

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Mazuet, C., Ezan, E., Volland, H., Popoff, M. R., & Becher, F. (2012). Toxin detection in patients’ sera by mass spectrometry during two outbreaks of type A botulism in France. Journal of Clinical Microbiology, 50(12), 4091–4094. https://doi.org/10.1128/JCM.02392-12

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