Diffuse neurofibrillary tangles with calcification: A new presenile dementia

Abstract

The term 'diffuse neurofibrillary tangles with calcification' (DNTC) is proposed for a new form of presenile dementia. It is characterised by slowly progressive cortical dementia in the presenium, localised temporal or temporofrontal lobar atrophy, numerous neurofibrillary tangles widespread in the cerebral cortex, and pronounced calcareous deposits; 16 cases of DNTC, have been reported.