De Novo vs Nevus-Associated Melanomas: Differences in Associations With Prognostic Indicators and Survival

55Citations
Citations of this article
77Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Background: Although 20% to 30% of melanomas are histopathologically 'nevus associated,' the majority of melanomas arise de novo, ie, in clinically normal skin with no associated nevus. We examined whether these forms of melanoma differed in their associations with clinical and histopathologic features and patient survival. Methods: We analyzed two prospective cohorts from our institution with protocol-driven follow-up information (NYU1, n = 1024; NYU2, n = 1125). We used univariate and multivariable analyses to examine associations between de novo vs nevus-associated melanoma classification and age, anatomic site, tumor thickness, tumor ulceration, mitotic index, histological subtype, clinical stage, and survival. We tested the associations identified in NYU1 using NYU2 as a replication cohort. All tests of statistical significance were two-sided. Results: In NYU1, de novo melanomas were associated with tumor thickness greater than 1.0 mm (odds ratio [OR] = 1.96, 95% confidence interval [CI] = 1.43 to 2.70, P

Cite

CITATION STYLE

APA

Cymerman, R. M., Shao, Y., Wang, K., Zhang, Y., Murzaku, E. C., Penn, L. A., … Polsky, D. (2016). De Novo vs Nevus-Associated Melanomas: Differences in Associations With Prognostic Indicators and Survival. Journal of the National Cancer Institute, 108(10). https://doi.org/10.1093/jnci/djw121

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free