Effects of Tween-80 on the Dissolution Properties of Daidzein Solid Dispersion in Vitro

Abstract

Objective Solid dispersions of daidzein (DZ) were prepared using tween-80 as the surfactant to improve its dissolution and solubility. Methods Using tween-80 as the surfactant and polyethylene glycol (PEG)-10000 as the carrier, solid dispersions of DZ were prepared by solvent method. Infrared spectroscopy (IR) and X-ray diffraction spectroscopy were applied to determine the status of DZ in carriers. Results When appropriate amount of Tween-80 was added into the solid dispersion, the dissolution of DZ could be improved obviously. The data of IR showed the absence of well-defined drug-polymer interactions. The data of X-ray diffraction showed that the drug might exist in the form of amorphism or molecule in solid dispersions. Conclusion Appropriate amount of Tween-80 could increase the dissolution rate of DZ.