Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

Abstract

An efficient and sustainable biocatalytic route for the synthesis of important 17-α-amino steroids has been developed using an ω-transaminase variant from Arthrobacter sp. Optimisation of the reaction conditions facilitated the synthesis of these valuable synthons on a preparative scale, affording excellent isolated yields and stereocontrol. © 2014 Partner Organisations.