Regenerative Therapy in Comprehensive Oral Rehabilitation for Pediatric Osteogenesis Imperfecta: A Case Report

Abstract

Osteogenesis imperfecta (OI) is a rare genetic condition marked by brittle bones and various degrees of skeletal deformity. It is also referred to as brittle bone disease. There are four forms of OI, and its management relies on preventing fractures and increasing bone strength, which becomes more difficult when treating a juvenile patient in a dental setting. A six-year-old child with OI, type 1, with a history of recurrent multiple fractures, complained of pain in his mandibular teeth. The patient was receiving biannual bisphosphonate injections for OI. During the initial dental appointment, the patient was apprehensive and afraid, but cooperative behavior was achieved using non-pharmacological behavior management techniques. Full mouth rehabilitation was done while restoring the vitality of carious permanent teeth using regenerative endodontic therapy. The patient was then followed up on a regular basis to ensure progressive apical root closure. Regenerative endodontics uses the concept of tissue engineering to restore the root canals to a healthy state, allowing for the continued development of the root and surrounding tissue. This case report discusses the issues in managing a pediatric patient with OI as well as the benefits of regenerative endodontic treatment therapy in preserving tooth vitality.