Prevalence and Characteristics of Diabetic Symmetric Sensorimotor Polyneuropathy in Japanese Patients with Type 2 Diabetes: The Japan Diabetes Complication and Its Prevention Prospective Study (JDCP Study 10)

Abstract

Aims/Introduction: We investigated the prevalence and characteristics of diabetic symmetric sensorimotor polyneuropathy (DSPN) in patients with type 2 diabetes registered in the JDCP (Japan Diabetes Complication and its Prevention Prospective) study. Materials and Methods: A total of 6,338 patients with diabetes were registered in 2007-2009. Of these, patients with type 2 diabetes who were able to be evaluated for DSPN were analyzed. DSPN was diagnosed using the Simple Diagnostic Criteria for Diabetic Polyneuropathy proposed by the Diabetic Neuropathy Study Group in Japan. Results: Of the total participants, 5,451 patients (mean age: 61.4 years old; mean duration of diabetes: 10.8 years) were analyzed. The prevalence of DSPN and sensory symptoms was 35.8 % and 25.8 %, respectively. The following factors increased the risk for DSPN: age (odds ratio 1.57; 95 % confidence interval 1.42-1.73), duration of diabetes (1.32; 1.21-1.43), body mass index (1.19; 1.09-1.30), systolic blood pressure (1.06; 1.01-1.10), hemoglobin A1c (1.15; 1.09-1.22), biguanides (1.22; 1.06-1.39), and insulin therapy (1.59; 1.36-1.84). The following factors decreased the risk for DSPN: total cholesterol (0.98; 0.96-1.00) and exercise therapy (0.85; 0.73-0.98). Conclusions: This survey clarified the prevalence, characteristics, and risk factors for DSPN in Japanese patients with type 2 diabetes.