(3+2)-cycloaddition reactions of oxyallyl cations

Abstract

The (3+2)-cycloaddition reaction involving oxyallyl cations has proven to be a versatile and efficient approach for the construction of five-membered carbo- and heterocycles, which are prevalent frameworks in natural products and pharmaceuticals. The following article will provide a brief summary of recent disclosures on this process featuring chemo-, regio- and diastereoselective oxyallyl cycloadditions with both electron-rich and electron-deficient 2π partners. 1 Introduction 2 Heteroatom-Substituted Oxyallyl Cations 3 Oxyallyl Cations Derived from Substituted Ketones 4 Oxyallyl Cations Intercepted from Nazarov Cyclization 5 1-Alkylidene-2-oxyallyl Cations 6 Summary and Outlook.