Effect of OU-1308 on uterine motility in pregnant rats and monkeys

Abstract

Effect of OU-1308 (17s, 20-dimethyl-6-oxo-prostaglandin E1 methyl ester) on uterine motility in anesthetized rats and monkeys was examined by means of the balloon catheter or openend catheter method and compared with that of PGF2α. OU-1308 and PGF2α exhibited uterine contractile activity at the dose of 30 μg/kg, i.v., on day 8 of pregnancy and 10 μg/kg, i.v., on day 20 of pregnancy in rats. In monkeys on day 50∼120 of pregnancy, both compounds enhanced uterine motility at 10, μg/kg, i.v. Intragastric administration of OU-1308 at 500 μg/kg, however, was without effect in monkeys. These results indicate that when administered intravenously, OU-1308 was as potent as PGF2α in terms of uterine contractile activity in pregnant rats and monkeys. © 1987, The Japanese Pharmacological Society. All rights reserved.