Organoid intelligence: smarter than the average cell culture

Abstract

KEYWORDS organoid, organoid intelligence, artificial intelligence, synapse, long-term potentiation A Viewpoint on the Frontiers in Science Lead Article Organoid intelligence (OI): the new frontier in biocomputing and intelligence-in-a-dish Key points • Advances in synthetic biology have allowed complex neuronal processes to be reliably studied in cultured organoids. • The intelligence capabilities possessed by brain organoids demand careful consideration of the ethical challenges posed by these systems. • Brain organoids represent an important model for studying how environmental factors disrupt components of neuronal function, including memory and cognition.