Evaluation of a latex agglutination test for detection of antibodies to rubella virus in selected sera

Abstract

A new latex agglutination test for rubella virus was used to test sera with a hemagglutination inhitibition titer of ≤8 (97 specimens) or ≥256 (158 specimens). Maximum latex agglutination test sensitivity was achieved when low-titer sera were tested undiluted and high-titer sera were diluted (1:10). A modification of the protocol of the manufacturer resulted in a latex agglutination-hemagglutination inhibition agreement of 96.7%.