Within tumors, interactions between T cells and tumor cells are impeded by the extracellular matrix

Abstract

In principle, T cells can recognize and kill cancer cells. However, tumors have the ability to escape T cell attack. By imaging the dynamic behavior of T cells in human lung tumor explants, we have recently established the importance of the extracellular matrix in limiting access of T cells to tumor cells. © 2012 Landes Bioscience.