Relationship between plasma levels of vitamin D in pregnant women and development of gestational diabetes mellitus

Abstract

Background: Gestational diabetes mellitus (GDM) is the leading cause of complications associated with childbirth for both mothers and offspring, and it is considered to be caused by the imbalance between insulin resistance and insulin secretion and contributed maternal hyperglycemia. This study aimed to assess the relationship between plasma levels of vitamin D in pregnant women and the development of gestational diabetes mellitus. Patients and Methods: A case-control study was conducted at Gynecology and Obstetrics Department, Zagazig University during the period from August 2020 until April 2021. It included a total of 104 pregnant women. Clinical and obstetrical data were gathered, 25(OH) vitamin D3 total level in ng/ml at week gestation (10-12), (24-26), and (34-36). The blood samples were performed by a Cobas 6000. Results: There is a strong correlation between vitamin D deficiency with the occurrence of gestational diabetes with a cut-off value of ≤14.1 at (10-12) weeks gestation, sensitivity 100%, specificity 97.83%, NPV 100%, and PPV 93.3%. Conclusions: There is an inverse association of vitamin D status with gestational diabetes risk.