Antiasthmatic activity of the ethanol extract of leaves of wrightia tinctoria

Abstract

Objective: The objective of this study was to evaluate the antiasthmatic activity of ethanolic extract of Wrightia tinctoria leaves in albino wistar rats. Methods: The plant extract was taken by soxhlet apparatus with 90% ethanol. Two methods are carried out such as milk-induced leukocytosis and ovalbumin-induced leukocytosis; (4 ml/kg) milk induced as intoxicant given by subcutaneous, (4 ml/kg) ovalbumin given by intraperitoneal injection, and standard drug as dexamethasone (50 mg/kg) given for both activity and drug extract for all three test groups (low, medium, and high) blood collected from the retro-orbital plexus and count the leukocytes before and after 24 h after drug administration. Result: Test 1, Test 2, and Test 3 groups were found to significantly (**p<0.01) decrease ambulation counts as compared to milk and ovalbumin control group. The treatment group was founded to significantly (**P<0.01) milk and ovalbumin control group increases ambulation count as compared to all test groups and standard groups. Conclusion: In this study, we conclude that an ethanolic extract of the leaves of W. tinctoria possesses a significant antiasthmatic property, which is probably mediated through inhibition of histamine. The activity shown by ethanolic extract of W. tinctoria was found to be dose dependent.