Pressure reversal of general anaesthesia-a multi-site expansion hypothesis

Abstract

We have quantitated the pressure reversal of continuous i.v. anaesthesia produced in rats by keta-mine, methohexitone, propanidid and thiopentone. These and other data are not consistent with the earlier critical volume hypothesis of general anaesthesia and therefore we postulate an alternative molecular mechanism-the multi-site expansion hypothesis. © 1978 Macmillan Journals Ltd.