Abstract
Background: The necessity for, or redundancy of, distinctive KChIP proteins is not known. Results: Deletion of KChIP2 leads to increased susceptibility to epilepsy and to a reduction in IA and increased excitability in pyramidal hippocampal neurons. Conclusion: KChIP2 is essential for homeostasis in hippocampal neurons. Significance: Mutations in K+ channel auxiliary subunits may be loci for epilepsy. Copyright © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Wang, H. G., He, X. P., Li, Q., Madison, R. D., Moore, S. D., McNamara, J. O., & Pitt, G. S. (2013). The auxiliary subunit KChIP2 is an essential regulator of homeostatic excitability. Journal of Biological Chemistry, 288(19), 13258–13268. https://doi.org/10.1074/jbc.M112.434548
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