Market Survey of Modern Oral Nicotine Products: Determination of Select HPHCs and Comparison to Traditional Smokeless Tobacco Products

Abstract

In an effort to combat the risks associated with traditional tobacco products, tobacco product innovation has been redirected towards reducing the consumer’s potential exposure to harmful or potentially harmful constituents (HPHCs). Among these innovations are modern oral nicotine products (MONPs). This product class aims to deliver nicotine while limiting the consumer’s potential toxicant exposure. This body of work sought to investigate the potential for select HPHC exposure (tobacco-specific nitrosamines, carbonyls, benzo[a]pyrene, nitrite, and metals) from MONPs and to compare it to that from traditional tobacco products. This work expands on previously published studies both in terms of diversity of products assessed and analytes tested. In total, twenty-one unique MONPs were assessed and compared to four traditional tobacco products. We found that there was a difference in the potential exposure based on the MONP filler—plant material vs. granulate/powder. Typically, the HPHC levels observed in plant-based MONPs were higher than those observed for granulate/powder products, most notably within the metals analysis, for which the levels were occasionally greater than those seen in traditional smokeless tobacco products. Generally, the overall HPHC levels observed in MONP were at or below those levels observed in traditional tobacco products.