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Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme

Angewandte Chemie - International Edition (2009) 48(44) 8268-8272
DOI: 10.1002/anie.200904209
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Abstract

Molecular orchestration: In the directed evolution of a hyperthermally stabilized enzyme, remote residues have been structurally coupled as a result of the creation of an extensive communicating amino acid network on the surface of the protein. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

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Reetz, M. T., Soni, P., Acevedo, J. P., & Sanchis, J. (2009). Creation of an amino acid network of structurally coupled residues in the directed evolution of a thermostable enzyme. Angewandte Chemie - International Edition, 48(44), 8268–8272. https://doi.org/10.1002/anie.200904209

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