"Synthesis of Some Novel Quinazoline Derivatives Having Anti-Cancer Activity"

Abstract

Cancers are the leading causes of morbidity and mortality worldwide. There are an estimated 14.1 million new cases of cancer in the world and the childhood cancers represent a small fraction of total cancers with the estimated values of 150,000 diagnosis each year. Cancers are a large family of diseases that involve abnormal cell growth with the potential to invade or spread to other parts of the body. Hence, some new semi carbazides containing quinazoline moieties have been synthesized and their ability to inhibit growth of human cancer cell lines has been evaluated. The compound S1 and S3 has shown remarkable anticancer activity. The structures of all the compounds have been confirmed by FT-IR, NMR, and mass spectral analysis.