Baclofen in parkinson's disease

Abstract

In a controlled trial, baclofen (mean dose 45 mg daily) significantly increased disability from Parkinsonism in 12 patients with the long-term levodopa syndrome. Peak dose choreoathetosis was not improved but benefit was observed in all four patients with "off period dystonia." Adverse side effects were common and severe, and included visual hallucinations, vomiting, and dizziness.