P085: Surveillance of drug-resistant Salmonella sp and Shigella sp infections in Rwanda

Abstract

Introduction: Salmonella sp. and Shigella sp infections are public health threat worldwide, particularly in Sub-Saharan Africa including in Rwanda. This study was done to identify Salmonella sp. and Shigella sp. currently circulating in Rwanda and determine their drug susceptibility pattern. Objectives: To determine the prevalence of Salmonella spp. and Shigella spp. strains circulating in Rwanda and their susceptibilty pattern in Rwanda. Methods: 196 blood and 24 stool specimens from patients were analyzed in Laboratory of Rwanda for culture isolation, identification and drugsensitivity testing. Results: 91 (92.2 %) of them were identified as Salmonella enterica serovar Typhi, 10 were Shigella sp. The isolates were subsequently subjected to antibiotic susceptibility tests and the strains of S. Typhi isolates were found to be susceptible to cefotaxime (100%), and ciprofloxacin (97.9 %) and resistant to nalidixic acid (89.4%), cotrimoxazole (87.2%). With regard to Shigella infections, the antibiotics which showed 100% susceptibility to all species identified were ciprofloxacine, cefotaxime, ceftazidine. Conclusion: The prevalent Salmonella strain circulating in Rwanda is S. Typhi and two most useful drugs of choice to treat Salmonella sp. and Shigella sp. infections in Rwanda are cefotaxime and ciprofloxacin.