A comprehensive review on blood brain delivery methods using nanotechnology

Abstract

A limited amount of the administered medicine can reach the brain. As a result, a higher dose of the drug must be administered, which, as expected, causes several undesirable side effects. For the past few decades, researchers in a range of professions have been working to address this highly important and frequently lethal condition. Nanomedicine is a field of research that has achieved promising findings in recent years. Nanomedicine is the science that combines nanotechnology, chemistry, and medicine. Many various forms of nano-medicine-based drug-delivery systems are currently being investigated with the express goal of improving drug delivery to the brain. This overview compiles and briefly summarizes some of the most significant advances in this crusade. Inorganic nano-particle-based drug delivery systems, such as gold and magnetic nano-particles, are discussed, as are several organic nano-particulate systems. Polymeric micelles and dendrimers are briefly described as organic drug-delivery nano-systems, while solid polymeric nano-particles are thoroughly investigated.