In Vitro Assessment of Cadmium Bioavailability in Chinese Cabbage Grown on Different Soils and Its Toxic Effects on Human Health

21Citations
Citations of this article
41Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The minimum concentration of cadmium (Cd), by Chinese cabbage grown on Cd contaminated soils that can initiate toxicity in human liver cells using in vitro digestion coupled with Caco-2/HL-7702 cell models was studied. Cadmium bioaccessibility in the gastric phase for yellow soil (YS) cabbage (40.84%) and calcareous soil (CS) cabbage (21.54%) was significantly higher than small intestinal phase with the corresponding values of 21.2% and 11.11%, respectively. Cadmium bioavailability was higher in YS cabbage (5.27%-14.66%) than in CS cabbage (1.12%-9.64%). Cadmium concentrations (>0.74 μg) transported from YS and CS cabbage were able to induce oxidative (MDA, H2O2) stress by inhibiting antioxidant (SOD, GPx) enzyme activities in human liver cells (HL-7702). Additionally the study revealed that the ingestion of Cd contaminated Chinese cabbage grown in acidic soil (yellow soil) weakened the antioxidant defense system under all levels of contamination (2, 6, and 9 mg·kg-1) which ultimately escalated the oxidative stress in liver cells; however, in case of CS cabbage, a marked oxidative stress was observed only at 9 mg kg-1 Cd level of soil. Therefore, it is necessary to monitor Cd concentrations in leafy vegetables grown on acidic soils to minimize human health risk.

References Powered by Scopus

Cellular mechanisms for heavy metal detoxification and tolerance

2483Citations
N/AReaders
Get full text

Autophagosome formation: Core machinery and adaptations

1881Citations
N/AReaders
Get full text

Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology

1288Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Toxicity of cadmium and its health risks from leafy vegetable consumption

193Citations
N/AReaders
Get full text

Cadmium accumulation characteristics in turnip landraces from China and assessment of their phytoremediation potential for contaminated soils

48Citations
N/AReaders
Get full text

Foliar application of zinc and selenium alleviates cadmium and lead toxicity of water spinach – Bioavailability/cytotoxicity study with human cell lines

47Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Aziz, R., Rafiq, M. T., He, Z., Liu, D., Sun, K., & Xiaoe, Y. (2015). In Vitro Assessment of Cadmium Bioavailability in Chinese Cabbage Grown on Different Soils and Its Toxic Effects on Human Health. BioMed Research International, 2015. https://doi.org/10.1155/2015/285351

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 19

79%

Researcher 4

17%

Professor / Associate Prof. 1

4%

Readers' Discipline

Tooltip

Environmental Science 9

50%

Nursing and Health Professions 3

17%

Agricultural and Biological Sciences 3

17%

Biochemistry, Genetics and Molecular Bi... 3

17%

Save time finding and organizing research with Mendeley

Sign up for free