A novel approach to the synthesis of α-aminonitriles using triphenyl-phosphine dibromide under solvent-free conditions

Abstract

A quick and highly efficient, one-pot, three-component, solvent-free method for the synthesis of α-aminonitriles starting from the corresponding carbonyl compounds, amines, and trimethylisocyanide using triphenylphosphine dibromide, has been developed. Diverse α-aminonitriles have been synthesized in good to excellent yields (80-99%) using a range of aldehydes, ketones and amines. © Georg Thieme Verlag Stuttgart · New York.