Abstract
We examined the in vitro activity of minocycline against 103 Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates and found approximately half had susceptible (26%) or intermediate (26%) MICs. For a subset of 35 isolates, susceptibility was highest to tigecycline (71% FDA vs. 20% EUCAST) followed by minocycline (14%) and then doxycycline (6%).
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Chen, A., Smith, K. P., Whitfield, B. A., Zucchi, P. C., Lasco, T. M., Bias, T. E., … Hirsch, E. B. (2017). Activity of minocycline against Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae clinical isolates, with comparison to doxycycline and tigecycline. Diagnostic Microbiology and Infectious Disease, 88(4), 365–367. https://doi.org/10.1016/j.diagmicrobio.2017.05.004
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