Reno protective effect of methanolic stevia rebaudiana bertoni leaves extract and its phenolic compounds in type-1- diabetes

Abstract

THEextract AIMof ofStevia this studyrebaudiana is to evaluatewhich showed the reno-protectivethe highestimprovement effect of theof defattedrenal parameters methanolic as it reduced the protein urea, blood urea nitrogen and blood creatinine and nephroprotective properties with reduced hyperglycemia complications through protection of renal tissues in type-1 diabetes. Also, identification of bioactive phenolic compounds of defatted methanolic extract using HPLC analysis, demonstrate the presence of diterpene glycosides, stevioside, rebaudioside A and chlorogenic acid.