Correlation of HbA1c with Serum Lipid Profile in Patients with Type 2 Diabetes Mellitus

Abstract

Background: Diabetes mellitus is a heterogeneous group of disease, characterized by a state of chronic hyperglycemia , resulting from a diversity of etiologies, genetic and environmental factors acting jointly.Glycated heamoglobin (HbA1c) is considered a gold-standard measure of chronic glycaemia in diabetic patients. HbA1c is a main indicator for mean blood glucose level. Dyslipidemia especially high LDL, is common in diabetes mellitus and strongly associated with poor glycaemia control. Objective-To find the correlation of HbA1C with lipid profile in patients with Type 2 Diabetes Mellitus. Material &Method: A total of 60 confirmed cases of type 2 diabetes mellitus were obtained from VIMSAR Medicine Department . The samples comprised both males and females. ( 40 -60 YR).60 subjects without dibetes of similar age group were taken as control. The parameters FBS, PPBS, HbA1c, TG, Chol, HDL, LDL, VLDL were studied and compared between case and control group. Observation: FBS,PPBS ,HbA1C were significantly high in case group. LDL,CHOL,TG were high in case as compared to control group, HDL is significantly low compared to control group. HbA1C /LDL ,HbA1C /HDL, HbA1C /CHOL statistically strongly significant results in patients when compared to controls. Result- HbA1c is significantly correlated with lipid profiles. Conclusion: Type 2 diabetic patients are more prone to dyslipidaemia. HbA1c is significantly correlated with lipid profiles. So HbA1c can be used as an indirect indicator of dyslipidaemia in type 2 diabetes in addition to as glycemic control biomarker. Keywards:Type 2 diabetes mellitus, HbA1c, lipid profil