Heterocycles of biological importance: Part 7. Synthesis of biologicallyactive pyrimido[2,1-b]benzothiazoles from acetylenic acids and2-aminobenzothiazoles

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Abstract

Conjugate addition of the imino nitrogen of 2-aminobenzothiazoles 1 to the alkyne β-carbon atom of acetylenic acids 2 followed by ring closure gives rise to novel 2H-pyrimido[2,1-b]-benzothiazol-2-ones in good yield.

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Wahe, H., Mbafor, J. T., Nkengfack, A. E., Fomum, Z. T., Cherkasov, R. A., Sterner, O., & Doepp, D. (2003). Heterocycles of biological importance: Part 7. Synthesis of biologicallyactive pyrimido[2,1-b]benzothiazoles from acetylenic acids and2-aminobenzothiazoles. Arkivoc, 2003(15), 107–114. https://doi.org/10.3998/ark.5550190.0004.f12

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