The times they are a-changin: Carbapenems for extended- spectrum-β-lactamase-producing bacteria

Abstract

Several antimicrobial agents are being investigated as alternatives to carbapenems in the treatment of infections caused by ESBLproducing Enterobacteriaceae, which may be useful in avoiding overuse of carbapenems in the context of recent global spread of carbapenem-resistant Enterobacteriaceae. The most promising candidates for invasive infections so far are β-lactam/β-lactamase inhibitor combinations and cephamycins.