Proton Magnetic Resonance Spectroscopy as a Potential Tool for Differentiating between Abdominal Fluid Collections

Abstract

Purpose: To determine the utility of proton magnetic resonance spectroscopy (MRS) in distinguishing abdominal fluid types. Materials and Methods: Abdominal fluid samples were obtained from patients undergoing therapeutic percutaneous drainage. In vitro spectroscopy was performed using a 1.5-T scanner and a head coil. Single voxel spectra were obtained using a point resolved spin-echo sequence with water suppression (TR/TE 2000 msec/35 msec). The peak pattern for each sample was examined and the signal-to-noise ratio (SNR) estimated (ratio of tallest peak to noise at <0 ppm). Results: Thirty-five samples were analyzed: purulent collection (eight). serosanguinous collection (eight), non-chylous ascites (six), chylous ascites (one), bile (seven), and bile with iodinated contrast media (five). The mean SNR of the dominant peak was: purulent collection, 12.7; serosanguinous collection, 3.2; non-chylous ascites. 2.4; chylous ascites, 8.8; bile, 1.4; and bile with contrast media, 60.8. Pus samples had a broad based peak pattern with continuous signal of > 1.5 ppm width situated within the range 0.2-2.5 ppm, not found in other samples. Chylous ascites (one sample) had a distinctive peak at 1.2 ppm. Bile with contrast had three peaks at 3.5/3.6, 2.6, and 2.1 ppm. No other patterns were found to be discriminatory. Common non-specific patterns seen included a bifid peak at 1.1-1.3 ppm and a broad based peak situated between 3 and 4 ppm. Conclusions: The H1 spectra of purulent fluid has a higher SNR than common non-purulent abdominal fluids and a distinct broad based peak pattern from 0.2-2.5 ppm. Proton spectroscopy may be a useful tool for distinguishing purulent from non-purulent intra-abdominal collections.