Differential contribution of insulin and amino acids to the mtorc1-autophagy pathway in the liver and muscle

Abstract

Background: The in vivo mechanism of autophagy regulation remains unclear. Results: The effect of insulin on mTORC1-autophagy is greater in muscle than in the liver, whereas that of amino acids is greater in liver than in muscle. Conclusion: Autophagy is differentially regulated by insulin and amino acids in a tissue-dependent manner. Significance: This information increases the understanding of protein homeostasis in vivo. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.