An unexpected role: UVA-induced release of nitric oxide from skin may have unexpected health benefits

Abstract

UVR has deleterious and beneficial effects on human health. In this issue, Liu et al. (2014) show that UVA decreases blood pressure and increases blood flow and heart rate in humans, which is beneficial to the cardiovascular system. This is likely mediated by UVA causing release of nitric oxide (NO) from skin stores. This mediator may have additional effects on human health. © 2014 The Society for Investigative Dermatology.