IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates

79Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

CD154-specific antibody therapy prevents allograft rejection in many experimental transplant models. However, initial clinical transplant trials with anti-CD154 have been disappointing suggesting the need for as of yet undetermined adjuvant therapy. In rodents, donor antigen (e.g., a donor blood transfusion), or mTOR inhibition (e.g., sirolimus), enhances anti-CD154's efficacy. We performed renal transplants in major histocompatibility complex-(MHC) mismatched rhesus monkeys and treated recipients with combinations of the CD154-specific antibody IDEC-131, and/or sirolimus, and/or a pre-transplant donor-specific transfusion (DST). Therapy was withdrawn after 3 months. Triple therapy prevented rejection during therapy in all animals and led to operational tolerance in three of five animals including donor-specific skin graft acceptance in the two animals tested. IDEC-131, sirolimus and DST are highly effective in preventing renal allograft rejection in primates. This apparently clinically applicable regimen is promising for human renal transplant trials. Copyright © Blackwell Munksgaard 2005.

References Powered by Scopus

The Banff 97 working classification of renal allograft pathology

2852Citations
N/AReaders
Get full text

CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells

1865Citations
N/AReaders
Get full text

Improved graft survival after renal transplantation in the United States, 1988 to 1996

1694Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Alefacept promotes co-stimulation blockade based allograft survival in nonhuman primates

164Citations
N/AReaders
Get full text

A new look at blockade of T-cell costimulation: A therapeutic strategy for long-term maintenance immunosuppression

134Citations
N/AReaders
Get full text

Induction immunosuppression

127Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Preston, E. H., Xu, H., Dhanireddy, K. K., Pearl, J. P., Leopardi, F. V., Starost, M. F., … Kirk, A. D. (2005). IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates. American Journal of Transplantation, 5(5), 1032–1041. https://doi.org/10.1111/j.1600-6143.2005.00796.x

Readers' Seniority

Tooltip

Researcher 8

62%

PhD / Post grad / Masters / Doc 4

31%

Lecturer / Post doc 1

8%

Readers' Discipline

Tooltip

Biochemistry, Genetics and Molecular Bi... 5

38%

Medicine and Dentistry 4

31%

Agricultural and Biological Sciences 2

15%

Immunology and Microbiology 2

15%

Save time finding and organizing research with Mendeley

Sign up for free