A Comparative Study of Coagulation Profile in Normal Pregnancy, Mild Preeclampsia, and Severe Preeclampsia Patients

Abstract

Introduction: Disorders of hypertension complicate approximately 5–10% of all pregnancies. Preeclampsia is a severe health issue that needs to be treated, especially in developing countries where it is more common and its risk of having detrimental effects is higher. This study assessed the severity of preeclampsia and coagulopathy to aid in the management of both situations before patients experienced complications as it is well known that an underlying coagulation disorder increases the risk of bleeding complications. Aim: The aim of this study was to compare coagulation profile in normal pregnancy, mild preeclampsia, and severe preeclampsia patients. Results: Preeclampsia patients’ platelet counts were found to be significantly lower, their bleeding times to be noticeably longer, and their D-dimers to be noticeably greater in the current study when they were contrasted with normotensive pregnant women. Conclusion: The coagulation profile is a crucial tool in the early detection of coagulation failure and its therapy to prevent the situation from getting worse. For a definitive diagnosis and therapy of the coagulation failure in preeclampsia and eclampsia patients, the use of additional parameters such as thrombin time, euglobulin clot lysis time, fibrinogen levels, and fibrinopeptide A is also recommended.