Abstract
The bio-transformation of 3-β-hydroxy-5, 16-dien-pregnane-20-one (CDRI 80/574, 1) a novel antagonist of farnesoid X receptor (FXR) on hepatic membranes, with Aspergillus niger produced the oxidation products at C3 and / or C11 (compound 2 and 3) while the Aspergillus ochraeus promoted the oxidation at C11 and / or C15 (compound 4 and 5). The products were characterized using 2D-NMR spectroscopy. ©ARKAT USA, Inc.
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Verma, A. K., Khemaria, P., Gupta, J., Singh, D. P., Joshi, B. S., Roy, R., … Pratap, R. (2010). Bio-transformation of FXR antagonist CDRI 80/574. Arkivoc, 2010(9), 1–11. https://doi.org/10.3998/ark.5550190.0011.901
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