Immune Thrombocytopenic Purpura As Sole Manifestation and Hemophagocytic Lypmhohistiocytosis As Sole Manifestation of Hepatitis a Virus Infection in Two Children

Abstract

Hepatitis A virus (HAV) infection is often asymptomatic or mildly symptomatic in pediatric population, the severity of the disease increases by age. Immune-mediated extrahepatic extrahepatic manifestations and hematologic complications are mainly reported in adults with acute and chronic hepatitis B and C. However, they are relatively rare in children with HAV infection. There are few available pediatric reports in English literature about autoimmune complications of HAV infection. We reported hematologic manifestations of HAV infection including hemophagocytic lymphohistiocytosis (HLH) and immune thrombocytopenic purpura as sole manifestations of HAV infection therefore in patients with these hematologic disorders, HAV infection should be kept in mind in the differential diagnosis even if they are not jaundiced.