P456 Quality of life is associated with wearable-based physical activity in patients with inflammatory bowel disease: a prospective, observational study

Abstract

Background: Inflammatory bowel disease (IBD) patients are at risk for an impaired quality of life, for example, due to the chronic relapsing character of the disease. Even though there a numerous emerging IBD therapies these Da ys, a cure of the disease is still not offerable. So, patient-reported outcomes such as quality of life are gaining importance in the assessment of patients. The association of objectively measured physical activity and quality of life in IBD patients has not been studied in depth. The present prospective, observational study was devised to analyse habitual physical activity in IBD patients and further investigate the link between physical activity and disease-specific quality of life. Method(s): 91 IBD patients were stratified into 4 groups (Crohn's disease (CD) and ulcerative colitis (UC), in remission and with moderate-severe activity, respectively), and evaluated with respect to disease-specific quality of life (IBDQ), habitual physical activity (accelerometry), body composition (bioelectrical impe Da nce analysis, BIA), as well as clinical (HBI, SCCAI) and biochemical (CRP, faecal calprotectin) parameters of disease activity. Result(s): In patients with moderate-severe disease activity, IBDQ was significantly lower when compared with patients in remission (Mann-Whitney U test and Kruskal-Wallis test, p < 0.001). The physical activity level (PAL) was higher in remission than in active disease (Mann-Whitney U test, p < 0.05). IBDQ was significantly correlated to the duration of strenuous physical activity per Da y (p = 0.029178, r = 0.235), skeletal muscle mass (p = 0.033829, r = 0.229), and biomarkers of inflammation (CRP: p < 0.005, r = -0.335, faecal calprotectin: p < 0.005, r = -0.385). Furthermore, patients with active disease had a significantly lower sleep efficiency. Conclusion(s): In this prospective, cross-sectional study, disease-specific quality of life was significantly associated with accelerometrically determined habitual physical activity as well as disease activity in patients with inflammatory bowel disease. This may be related to a reciprocal impact of these factors. Habitual physical activity, IBDdisease activity as well as health-related quality of life closely correlate with each other and should be taken in account during doctors' visits to further improve patients general well-being and establish a system of quality of life modifiers next to medical therapies.