Teicoplanin, Antibiotics from Actinoplanes Teichomyceticus Nov. SP. VI. Chemical Degradation: Physico-Chemical and Biological Properties of Acid Hydrolysis Products

Abstract

Teicoplanin is an antibiotic complex consisting of five closely related factors, T-A2-1,2,3, 4 and 5 and a more polar factor, T-A3-1. By controlled acid hydrolysis the complex is transformed into pseudoaglycones and finally into a single aglycone with consecutive removal of three sugar units. Quantitative determination of sugars obtained by degradative reactions and NMR/LC-MS studies on suitable derivatives confirmed that all the components carry one N-acyl-D-glucos-amine and that at least two of them are characterized by N-decanoyl and N-undecanoyl chains on the D-glucosamine unit. The hydrolysis products still possess in vitro and in vivo activity. © 1984, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.