Vitamin K deficiency and osteopenia in vitamin D-deficient elderly women with Parkinson’s disease

Abstract

Objective: To assess the influence of vitamin K on bone mineral density (BMD) in vitamin-D-deficient women with Parkinson’s disease (PD). Design: Cross-sectional study. Setting: Neurology department at a university medical center in Japan. Participants: Sixty-two women with PD (mean age, 70.7yr) and 62 age-matched controls. Patients were divided into 2 groups according to their functional capabilities: group A (independent: stages I-II of Hoehn and Yahr stages of Parkinson’s disease, n = 26); and group B (dependent: Hoehn and Yahr slages 3-5; n = 36). Interventions: Not applicable. Main Outcome Measures: Sera were analyzed to relate vitamin K concentrations to bone-related biochemical indices. BMD was measured by computed radiograph densitometry. Results: Group B had significantly lower metacarpal BMD (P