SP390ANALYSIS OF LIPID PROFILE IN RELATION TO ECHOCARDIO GRAPHIC PARAMETERS IN CHRONIC KIDNEY DISEASE STAGE5 COMMENCING MAINTAINANCE HEMODIALYSIS

Abstract

BACKGROUND: Cardiovascular disease is important cause of morbidity and mortality in CKD. AIM OF THE STUDY: We aim to analyse the major risk factor dyslipidemia in relation to echocardiographic parameters in CKD stage5 patients commencing MHD. METHODS: We retrospectively analysed the data of stable CKD stage 5 patients who were to be initiated on MHD between 2011 to 2015 and parameters like hemoglobin; RFT; LFT; calcium; phosphorus; uric acid; PTH; Vitamin D; hsCRP; lipid profile and echocardiogram were collected. We excluded all those with an evidence of severe sepsis; respiratory failure and acute vascular events. We analysed the association between lipid profile and echocardiographic parameters after excluding those on statin therapy. RESULTS: There were total 394 patients with mean age of 47.6±18.2 years(male-264/female-130). Among them 148(37.6%) were diabetics and 255(64.7%) were hypertensive. There was history of CAD in 56(14.2%) and stroke in 10(2.5%). Mean levels of Total cholesterol(TC)-138.2±56.2mg/dl; HDL cholesterol (HDL C)-37.5±21.7mg/dl; LDL cholesterol (LDL C)-76.2±44.8mg/dl and triglycerides(TG)-120.1±75.6mg/dl. Concentric LVH was seen in 68(17%); systolic dysfunction in 28(7%); diastolic dysfunction in 55(14%) and aortic sclerosis in 30(7%). TC (mean-138.2±56.2mg/dl) and LDL C(mean- 76.2±44.8mg/dl) levels were associated with both systolic and diastolic dysfunction. CONCLUSIONS: Concentric LVH is the most common echocardiographic abnormality seen in our group of patients with relatively age commencing MHD.TC and LDL C are associated with both systolic and diastolic dysfunction.