Fluoride excess in coccidioidomycosis patients receiving long-term antifungal therapy: An assessment of currently available triazoles

Abstract

The use of voriconazole, a trifluorinated antifungal, has been associated with the development of fluoride excess and periostitis/ exostoses. We evaluated a cohort of patients on long-term triazole therapy and found that other fluorinated triazoles (fluconazole and posaconazole) conferred no risk for the development of hyperfluorosis and its complications in our cohort. Copyright © 2012, American Society for Microbiology. All Rights Reserved.