Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Cutaneous Squamous Cell Carcinoma 2025

Abstract

This revision work was commissioned by the Japanese Dermatological Association (JDA) and was undertaken by a committee of experts in related fields. The committee prepared comprehensive, evidence-based guidelines by thoroughly reviewing and systematizing a wide range of literature on cutaneous squamous cell carcinoma. The literature search was conducted by the Japan Medical Library Association. Recommendations were prepared using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) scheme. These guidelines were prepared in accordance with the “Minds Clinical Practice Guideline Preparation Manual 2020 ver. 3.0”. Six clinical questions were established, and corresponding recommendations were described for each. CQs addressed the following: (1) the treatment of early lesions, (2) the possibility of reduction surgery for primary lesions, (3) the significance of sentinel lymph node biopsy, (4) the possibility of non-surgical treatment as an alternative to surgical treatment, (5) follow-ups after treatment, and (6) drug treatment for advanced stages. We are confident that the JDA Clinical Practice Guidelines for Cutaneous Squamous Cell Carcinoma will contribute to improving the treatment of cutaneous squamous cell carcinoma in Japan and worldwide.