Synthesis and applications of new trans 1-indolyl-2-(1-methyl pyridinium and quinolinium-2-yl)ethylenes

Abstract

The synthesis and spectroscopic characterization of trans 1-(indol-2-yl)-2-(1-methylpyridinium and 1-methylquinolinium-2-yl) ethylenes is reported. In vitro antitumour activity tests show that quinolinium derivatives are more active towards MCF7 (breast), LNCap (prostate) and U87 (human gliobastoma) carcinoma cells than pyridinium ones.