Megakaryocytes tame erythropoiesis with TGFb1

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Abstract

In this issue of Blood, Di Giandomenico et al have used a megakaryocyte (MK)specific tgfb1 knockout strategy to identify an unsuspected physiological role of MKs in regulating steady-state erythropoiesis by restraining progenitor cell and erythroblast (ERB) production.1

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Villeval, J. L., & Vainchenker, W. (2020). Megakaryocytes tame erythropoiesis with TGFb1. Blood, 136(9), 1016–1017. https://doi.org/10.1182/blood.2020006906

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