Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading

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Abstract

Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL-1. The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity.

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Zhang, F., Khan, S., Li, R., Smolen, J. A., Zhang, S., Zhu, G., … Wooley, K. L. (2017). Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading. Nanoscale, 9(41), 15773–15777. https://doi.org/10.1039/c7nr05935c

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