Multifunctional polyphosphoester-based nanoparticles capable of loading paclitaxel (PTX) both chemically and physically were prepared, achieving an ultrahigh equivalent PTX aqueous concentration of 25.30 mg mL-1. The dual-loaded nanoparticles were effective in killing cancer cells, which has the potential to minimize the amount of nanocarriers needed for clinical applications, due to their ultrahigh loading capacity.
Zhang, F., Khan, S., Li, R., Smolen, J. A., Zhang, S., Zhu, G., … Wooley, K. L. (2017). Design and development of multifunctional polyphosphoester-based nanoparticles for ultrahigh paclitaxel dual loading. Nanoscale, 9(41), 15773–15777. https://doi.org/10.1039/c7nr05935c