Comparative effectiveness of long-Acting antipsychotics: Issues and challenges from a pragmatic randomised study

Abstract

Although long-Acting antipsychotics are widely used in individuals with psychotic disorders, it is unclear which long-Acting preparation should be considered as first-line treatment in clinical practice. In this commentary, the main strengths and weaknesses of a recently published pragmatic randomised study comparing long-Acting paliperidone palmitate v. long-Acting haloperidol decanoate are briefly analysed.