Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins

Fatma Boukattaya; Andrii Stanovych; Paul Setzer; Souhir Abid; Houcine Ammar; Morwenna S.M.Pearson Long; Philippe Bertus

Journal Article

Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins

Chemical Communications (2012) 48(69) 8655-8657

DOI: 10.1039/c2cc34841a

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Abstract

The double addition of Grignard (alkyl, aryl, alkenyl, alkynyl) reagents to acyl cyanohydrins was performed under unusually smooth conditions with a concomitant O–N acyl transfer, providing a very simple and general access to α,α,α-trisubstituted amides. © 2012 The Royal Society of Chemistry.

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Boukattaya, F., Stanovych, A., Setzer, P., Abid, S., Ammar, H., Long, M. S. M. P., & Bertus, P. (2012). Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins. Chemical Communications, 48(69), 8655–8657. https://doi.org/10.1039/c2cc34841a

Simple and convenient access to α,α,α-trisubstituted amides by double addition of Grignard reagents to acyl cyanohydrins

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