Pyrazinamide: An essential drug in the tuberculosis treatment

Abstract

Pyrazinamide (PZA) is an important drug used against tuberculosis that helped to decrease the time of treatment from twelve to six months. The main action of this drug is the elimination of dormant bacilli, which are responsible for the emergence of resistant strains. However, few analogs have been synthesized with the purpose to explore and develop new compounds more effective and selective against M. tuberculosis. In this context, this review aims to highlight the importance of PZA in the treatment of tuberculosis as well as the development of new substances based on this drug with potential antimycobacterial activities.